After tracing the antecedents of the concept and considering its intersection in social innovation research, we put forward the argument that the Anthropocene concept points to three areas of thought that are strategically imperative and must be accelerated if social innovation theory and practice is to prove transformative and respond to the challenges associated with the Anthropocene. First, we contend that the current debate on social innovation for sustainability lacks a deeper focus on human-environmental interactions and the related feedbacks, which will be necessary to understand and achieve large-scale change and transformations to global sustainability. Many innovations focus on only the social or the ecological, and we believe a more integrated approach will be needed moving forward. Second, social innovation research must confront the path-dependencies embedded within systems, and we propose that the act of “bricolage,” which recombines existing elements in novel ways, will be essential, rather than single variable solutions, which currently dominate social innovation discussions. Finally, we put forward the idea that confronting the cross-scalar nature of the Anthropocene requires revisiting both the scope and temporal nature of social innovations that are most typically focused upon by scholars and funders alike.